Friday, June 12, 2015

Parp Inhibitor Trial

I am currently in a tial that inhibits cancer cells from repairing themselves.

" PARP inhibitors capitalize on the Achilles’ heel of BRCA1/2-mutated cells whose DNA repair mechanisms are already impaired. Researchers know that the action of a PARP (poly ADP-ribose polymerase) inhibitor serves to fully disable the tumor cell’s ability to repair its damaged DNA, leading to what is known as synthetic lethality, while normal cells suffer little-to-no effect on their ability to survive.
- See more at: http://www.onclive.com/conference-coverage/mbcc-2015/Excitement-Building-for-PARP-Inhibitors-in-BRCA-Mutated-Breast-Cancer#sthash.c0qOVeLU.dpuf" 

I take an oral pill combined with infusions of chemo. The informaion for the trial is below. You can contact the sponsor directly to see if there is one near you. The oral drup has been FDA approved for other cancers and now they are trying it for breast/mets.

Title: A phase 3 randomized, placebo-controlled Trial of Carboplatin and Paclitaxel with or without the PARP inhibitor Veliparib (ABT-888) in HER 2-negative metastatic or locally advanced unresectable BRCA-Associated breast cancer.

Sponsor: AbbVie Inc.

Investigator: Henry Kaplan MD
1221 Madison St. Seattle WA 98104

What is it? : https://en.wikipedia.org/wiki/PARP_inhibitor

A little background: http://www.onclive.com/conference-coverage/mbcc-2015/Excitement-Building-for-PARP-Inhibitors-in-BRCA-Mutated-Breast-Cancer

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